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Optimizing Heart Failure Management: A High-Intensity, Patient-Centered Approach to Guideline-Directed Medical Therapy

Cardiology
Curriculum:
Optimizing Heart Failure Management: A High-Intensity, Patient-Centered Approach to Guideline-Directed Medical Therapy
Launch Date:
August 12, 2025
Expiration Date:
The accreditation for this activity has expired.

Primary Audience:

Cardiologists, emergency medicine, critical care, and primary care physicians, in addition to other healthcare professionals involved in the diagnosis, management, and treatment of patients with heart failure.

Relevant Terms:

Guideline-directed medical therapy; guidelines; heart failure (HF); heart failure with reduced ejection fraction (HFrEF); heart failure with preserved ejection fraction (HFpEF); therapy; medications; implementation; treatment initiation; treatment uptitration

Gianluigi Savarese, MD, PhD, FESC, FHFA

Professor of Cardiology and Senior Lecturer
Head of the Heart Failure and Arrhythmia Research Group
Department of Clinical Science and Education
Karolinska Institutet, Stockholm, Sweden

Senior Consultant for Heart failure 
Southern Hospital, Stockholm, Sweden

Gianluigi Savarese is an Italian/Swedish cardiologist, currently Professor of Cardiology and Senior Lecturer at Karolinska Institutet (Department of Clinical Science and Education) where he is head of the Center for Heart Failure and Arrhythmia. He is also Senior Consultant for Heart Failure at the Southern Hospital, Stockholm, Sweden. Over the last few years, he has published >300 articles in top peer-reviewed journals. The major focus of his research is heart failure, with a particular interest in implementing use of guideline-recommended treatments, and phenotyping heart failure for improving clinical trial design. He is heavily involved in registry studies (Swedish Heart Failure Registry, ESC registries) and clinical trials, and he is expert in meta-analysis and big data analysis. He is Secretary of the Heart Failure Association, and he has served as board member and secretary of the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology. Among others, he is Deputy Editor of EHJ-Open, EHJ-CR, and Associate Editor of European Journal of Heart Failure.

David Sim, MD

Doctor
National Heart Centre, Singapore

Dr. David Sim is the Head and Senior Consultant in the Department of Cardiology, Director of the Heart Failure Program, and Director of Clinical Trials at the National Heart Centre Singapore (NHCS). He is also Past President of the Heart Failure Society (Singapore) and serves as an Associate Professor at Duke-NUS Medical School.
 
With expertise in heart failure, mechanical circulatory support, and heart transplantation, Dr. Sim is a national leader for Singapore in multiple global heart failure clinical trials. He is also a member of the adult heart transplant committee at NHCS and has a strong interest in palliative care for advanced heart failure, leading the Advanced Care Planning Program at NHCS.
 
Dr. Sim completed a fellowship in heart failure and heart transplantation at The Alfred Hospital, Melbourne, and is a Member of the Royal College of Physicians, UK. Internationally, he actively contributes to developing heart failure programs in Mongolia and Vietnam and serves as an advisor to the Shastin National Heart Centre of Mongolia.

Clara Inés Saldarriaga-Giraldo, FACC, FESC, FSIAC

Professor
University of Antioquia, Medellín, Colombia

Prof. Clara Saldarriaga is a Professor of Cardiology at the University of Antioquia and Head of the Cardiology Program at Pontificia Bolivariana University in Medellín, Colombia. She was the first woman to serve as President of the Colombian Society of Cardiology.
 
Her research focuses on heart failure, cardiovascular disease in women, and developing new care models for low- and middle-income countries. She is an experienced clinical trialist, serving as a principal investigator and Steering Committee member for multiple heart failure studies.
 
Beyond her research, Prof. Saldarriaga is passionate about mentoring early-career cardiologists, particularly women in the field. She actively collaborates with organizations like Women as One to support female professionals in cardiology.
 
She is also a member of the Lancet Commission for Cardiovascular Disease in Women and an Editorial Board member for Cardiac Failure Review.

Shelley Zieroth, MD, FCCS, FHFSA (hon), FESC, FACC, FHFA, FRCPC

Doctor
University of Manitoba, Winnipeg, Canada

Dr. Shelley Zieroth joined the Section of Cardiology at St. Boniface Hospital in Winnipeg in July 2006. She is currently a Professor in the College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, as well as Director of the Heart Failure Clinics. She is also Head of the Medical Heart Failure Program for Cardiac Sciences Manitoba.
 
Dr. Zieroth attended medical school at the University of Manitoba and went on to train in Internal Medicine and Cardiology at the same center. She completed her Postdoctoral Clinical Fellowship, specializing in Advanced Heart Failure and Cardiac Transplant, at Toronto General Hospital.
 
Her research interests include heart failure and cardio-kidney-metabolic interactions.  She holds leadership positions in international clinical trials and has enrolled many patients in landmark clinical trials during the course of her career. She is also Associate Editor at JACC HF, European Journal of HF and the European Heart Journal.
 
She is a governor-elect for ACC representing Canada and Past President of the Federation of Medical Women of Canada. Other leadership roles include Past President of the Canadian Heart Failure Society, and she has been a longstanding contributor and now co-Chair of the Canadian Cardiovascular Society Heart Failure Guidelines.  She serves as Co-Chair of Canada’s largest annual heart failure meeting, HF Update.

Carsten C. Tschöpe, FESC, FHFA

Prof. Dr. med.
Charité University Hospital, Berlin, Germany

Prof. Dr. Carsten Tschöpe is a leading cardiologist and researcher, specializing in heart failure, myocarditis, and cardiomyopathies. He heads the Clinical Cardiomyopathy Unit at the Deutsches Herzzentrum der Charité (DHZC) and the Translational Cardiovascular Unit at the Berlin Institute of Health (BIH) and BCRT. He is also a Professor of Medicine and Cardiology at Charité in Berlin.
 
With over 550 publications, Prof. Tschöpe is a pioneer in immunocardiology, focusing on the role of the immune system in heart failure and cardiac regeneration. He is a board member of the Heart Failure Association (HFA) and Chair of the ESC Working Group on Myocardial and Pericardial Diseases. His research explores innovative treatment strategies, including regenerative medicine and immunotherapies for cardiac repair.
 
He is recognized among the world’s top experts in myocarditis and has conducted over 50,000 heart biopsies, making him one of the most experienced interventional cardiologists in this field. Prof. Tschöpe also contributes to the development of cardiomyopathy programs in Europe, holding a guest professorship at the University of Wroclaw.
1. Define the components of guideline-directed medical therapy (GDMT) for patients for heart failure  and review the evidence supporting early initiation of GDMT into clinical practice to improve patient outcomes.
2. Review the rationale for implementing high-intensity guideline-directed medical therapy (GDMT) across the full spectrum of ejection fraction in heart failure.
3. Apply best practices for the diagnosis and implementation of GDMT in patients with heart failure who are frail or at-risk of frailty.
4. Apply best practices for the assessment and implementation of GDMT in patients with heart failure and chronic kidney disease.
5. Apply best practices for the assessment and implementation of GDMT in patients with heart failure and low blood pressure.
6. Apply best practices for the assessment and implementation of GDMT in patients with heart failure with preserved ejection fraction (HFpEF).
7. Apply best practices for identifying and addressing socioeconomic barriers to the implementation of GDMT in patients with heart failure.

This activity has been accredited by the European Board for Accreditation of Continuing Education for Health Professionals (EBAC®).
 
Through an agreement between the European Board for Accreditation of Continuing Education for Health Professionals and the American Medical Association physicians may convert EBAC® CE credits to AMA PRA Category 1 Credits. Information on the process to convert EBAC credit to AMA credit can be found on the AMA website. Other health care professionals may obtain from the AMA a certificate of having participated in an activity eligible for conversion of credit to AMA PRA Category 1 Credit.

To receive your CME certificate please complete the online evaluation, accessible via QR code, at the end of the activity.
 

COURSE VIEWING REQUIREMENTS

Supported Browsers:
Microsoft Edge
Google Chrome 60 or higher
Mozilla Firefox 60 or higher
Apple Safari 11.0 or higher
For video, install the latest version of Quicktime.
Supported Phones & Tablets:
iOS 9.3 and higher
Android 7.0 (Nougat or higher)
Microsoft Windows 8
Chrome OS

 
Additional Recommendations and Requirements
Display Resolution & Color Depth Resolution
- 960 X 768 minimum
- 1024 X 768 recommended min.

Color Depth
- 8 bits (256 colors) minimum
- 16 bits (High colors) minimum
Audio - Microphone
- Speakers or headphones
- Audio recording support
Word Processing Software that can open, modify, and save documents in Rich Text Format (RTF). Microsoft Word and PowerPoint are recommended.